Chicken Tzatziki Casserole

This one-pan Chicken Tzatziki Casserole is packed with bold Mediterranean flavors. Juicy chicken breast, zucchini, and tomatoes bake with fragrant basmati rice in a seasoned broth, creating a hearty yet fresh dish. Topped with creamy tzatziki, tangy pickled onions, and crumbled feta, every bite is a perfect balance of zesty, savory, and creamy flavors.

This recipe is ideal for a weeknight dinner, meal prep, or a crowd-pleasing dish for gatherings. Serve it with warm pita bread for a complete and satisfying meal.

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Part 1: Ingredients & Step-by-Step Instructions

Why You’ll Love This Recipe

• One-pan meal – Easy preparation and minimal cleanup.
• Mediterranean flavors – A blend of fresh, zesty, and creamy elements.
• Balanced and hearty – Protein-packed chicken, fiber-rich rice, and vegetables.
• Make-ahead friendly – Perfect for meal prep or batch cooking.

Essential Tools and Equipment

• 9×13-inch baking dish – Ensures even cooking and proper baking.
• Mixing bowls – For combining seasonings and pickling onions.
• Measuring cups and spoons – Ensures accuracy in ingredients.
• Sharp knife and cutting board – For dicing chicken and vegetables.

Ingredients

For the Casserole

• 1.5 lbs chicken breast, diced
• 1 zucchini, sliced
• ½ yellow onion, diced
• 1 pint grape tomatoes
• 1½ cups uncooked basmati rice
• 1 lemon, cut into wedges
• ¼ cup crumbled feta, plus extra for serving
• 3 cups chicken stock
• 2 tablespoons Greek seasoning

Paprika Spice Mix

• 2 teaspoons smoked paprika
• 1 teaspoon seasoning salt
• ½ teaspoon turmeric
• ¼ – ½ teaspoon cayenne pepper

Pickled Onions

• 1 red onion, thinly sliced
• ¾ cup red wine vinegar
• 2 teaspoons sugar
• 2 teaspoons salt

Toppings

• Extra feta cheese
• Tzatziki sauce
• Pickled onions
• Chopped parsley
• Pita bread, for serving

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Step-by-Step Directions

Step 1: Prepare the Seasoning and Pickled Onions

1. Make the Paprika Spice Mix – In a small bowl, mix together smoked paprika, seasoning salt, turmeric, and cayenne pepper. Set aside.
2. Pickle the Onions – In a saucepan, heat red wine vinegar with sugar and salt until dissolved. Remove from heat, add sliced onions, and refrigerate for at least 30 minutes.

Step 2: Assemble the Casserole

1. Preheat the oven to 375°F (190°C).
2. In a 9×13-inch baking dish, layer diced chicken, basmati rice, zucchini, diced onion, and grape tomatoes.
3. In a mixing bowl, combine chicken stock with Greek seasoning and the prepared Paprika Spice Mix.
4. Pour the seasoned stock mixture evenly over the casserole ingredients.

Step 3: Bake the Casserole

1. Cover the dish with foil and bake for 40 minutes.
2. Remove the foil, then bake for an additional 10 to 20 minutes, until the rice is tender and the liquid is absorbed.

Step 4: Serve and Garnish

1. Fluff the casserole gently with a fork to separate the rice.
2. Top with extra crumbled feta, tzatziki sauce, and pickled onions.
3. Garnish with chopped parsley and serve with lemon wedges.
4. Pair with warm pita bread for an authentic Mediterranean experience.

How to Serve Chicken Tzatziki Casserole

This casserole is a complete meal on its own, but pairing it with complementary side dishes enhances the flavors and textures. Here are some excellent serving suggestions:

Best Side Dishes

1. Hummus and Pita Chips – Adds extra creaminess and crunch.
2. Greek Salad – A mix of crisp cucumbers, tomatoes, Kalamata olives, and feta cheese.
3. Roasted Garlic Green Beans – A light and flavorful vegetable side.
4. Lemon Roasted Potatoes – A tangy and crispy addition that pairs well with tzatziki.
5. Grilled Eggplant and Zucchini – Enhances the Mediterranean flavors of the dish.
6. Tzatziki and Warm Pita Bread – Perfect for dipping and scooping.
7. Stuffed Grape Leaves (Dolmas) – A classic Greek appetizer with a rich, herby filling.
8. Marinated Olives – Adds a salty, briny contrast to the creamy toppings.

Common Mistakes to Avoid

Not Rinsing the Rice

Basmati rice should always be rinsed under cold water until the water runs clear. This removes excess starch, preventing the rice from becoming sticky or mushy.

Overcooking the Chicken

Dicing the chicken into even-sized pieces ensures that it cooks at the same rate as the rice. Overcooked chicken can become dry, so following the recommended baking time is key.

Skipping the Pickled Onions

Pickled onions add a tangy contrast that balances the creamy and savory elements of the dish. They are quick to make and should not be skipped.

Using Too Much Liquid

Adding too much stock can make the rice overly soft. Stick to the recommended measurements, and adjust only slightly if using different types of rice.

Not Fluffing the Casserole After Baking

Fluffing the rice after baking helps separate the grains and prevents clumping. This simple step improves the overall texture of the dish.

Using Cold Chicken Stock

Warm or room-temperature stock absorbs into the rice more efficiently, leading to better texture and flavor distribution. Cold stock can slow down the cooking process.

By keeping these tips in mind, you can ensure that your Chicken Tzatziki Casserole turns out perfect every time.

Storage and Reheating Tips

Refrigeration

Store leftovers in an airtight container in the refrigerator for up to four days. Allow the casserole to cool completely before storing to prevent excess moisture buildup.

Freezing

For longer storage, freeze individual portions in freezer-safe containers for up to three months. When ready to eat, thaw in the refrigerator overnight before reheating.

Reheating Methods

• Microwave – Place a portion in a microwave-safe dish and heat for one to two minutes, stirring halfway through.
• Oven – Reheat in a covered baking dish at 350°F for 15 minutes or until warmed through. Adding a splash of chicken stock can help maintain moisture.
• Stovetop – Heat in a skillet over low heat, adding a little broth or water to keep the rice from drying out.

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Frequently Asked Questions

Can I use brown rice instead of basmati?

Yes, but brown rice requires a longer cooking time and additional liquid. Increase the baking time by 15 to 20 minutes and add an extra half cup of chicken stock.

Can I make this casserole ahead of time?

Yes. Assemble the casserole, cover it tightly, and refrigerate for up to 24 hours before baking. When ready to cook, bake as directed, adding a few extra minutes if needed.

What protein substitutes work for chicken?

Shrimp, ground turkey, or chickpeas are great alternatives. Shrimp should be added in the last 10 to 15 minutes of baking to prevent overcooking.

Is this recipe gluten-free?

Yes, this dish is naturally gluten-free. Ensure that your Greek seasoning and other ingredients do not contain added gluten.

What is the best way to make homemade tzatziki?

To make tzatziki from scratch, mix Greek yogurt, grated cucumber, minced garlic, lemon juice, olive oil, salt, and fresh dill. Let it sit in the refrigerator for at least 30 minutes to develop the flavors.

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Conclusion

This Chicken Tzatziki Casserole is an easy, flavorful meal that brings together the best of Mediterranean cuisine. With juicy chicken, fluffy rice, fresh vegetables, and creamy tzatziki, every bite is packed with vibrant flavors and satisfying textures.

Perfect for weeknight dinners, meal prep, or family gatherings, this one-pan dish is a convenient and delicious way to enjoy a hearty Mediterranean-inspired meal. Try it today and experience a fresh, zesty, and comforting dish that is sure to become a favorite.